The Science of Hunger & Medications to Combat Obesity | Dr. Zachary Knight
Descripción del Episodio
In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied.
We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss.
Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health.
For show notes, including referenced articles and additional resources, please visit hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
BetterHelp: https://betterhelp.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Waking Up: https://wakingup.com/huberman
LMNT: https://drinklmnt.com/huberman
Timestamps
00:00:00 Dr. Zachary Knight
00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up
00:07:07 Hunger & Timescales
00:11:28 Body Fat, Leptin, Hunger
00:17:51 Leptin Resistance & Obesity
00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons
00:30:26 Sponsor: AG1
00:32:15 Body Weight & Obesity, Genes & POMC Neurons
00:39:54 Obesity, Genetics & Environmental Factors
00:46:05 Whole Foods, Ultra-Processed Foods & Palatability
00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning
00:58:55 Calories vs. Macronutrients, Protein & Salt
01:02:23 Sponsor: LMNT
01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure
01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy
01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea
01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects
01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133
01:34:49 Alpha-MSH & Pharmacology
01:40:41 Dopamine, Eating & Context
01:46:01 Dopamine & Learning, Water Content & Food
01:53:23 Salt, Water & Thirst
02:03:27 Hunger vs. Thirst
02:05:46 Dieting, Nutrition & Mindset
02:09:39 Tools: Improving Diet & Limiting Food Intake
02:14:15 Anti-Obesity Drug Development
02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter
Learn more about your ad choices. Visit megaphone.fm/adchoices
Episodios Recientes
Más podcasts de Sociedad y Cultura
Ver toda la categoría →
All Ears English Podcast
By shows
Are you looking for a new and fun way to learn American English? Come hang out with Lindsay and Michelle from Boston and New York City and have fun while you improve your English listening skills! We are an English as a Second Language (ESL) podcast for intermediate to advanced English learners around the world. We will show you how to use everyday English vocabulary and natural idioms, expressions, and phrasal verbs and how to make small talk in American English. We will also give you special tips on American culture, customs, etiquette, and how to speak with Americans as well as conversation and commentary on study tips, business English, life in America and Boston and New York, how to apply to university in the US, dating, travel, food and more. You'll get TOEFL, IELTS, and TOEIC help also from The Examiner of Excellence, Jessica Beck. This podcast is for adult students who are professionals and university students as well as ESL teachers. Join the community to learn to speak American English like a native! Connection NOT Perfection!
Vamos pa' eso
By shows
<p>Vamos Pa' Eso, su podcast, es una plataforma dedicada al análisis de casos de personas que han sido víctimas y se encuentran involucradas en un juicio o en algún proceso legal en curso. Estas personas comparten sus historias para explicar a la audiencia qué acciones se pueden tomar en este tipo de situaciones y cómo funciona el sistema legal en Colombia.</p>
Expediente No Humano
By shows
No Humano es el podcast donde Fepo y Fermex desentrañan el misterio más inquietante de nuestra era: el fenómeno no-humano. Abducciones, contacto, tecnología imposible, testimonios y evidencia real que apuntan a una presencia inteligente que no es de este mundo.
The Zach Lowe Show
By shows
Same Zach. New home. The Zach Lowe Show keeps you in the know around the Association with a variety of NBA conversations and game breakdowns. Plus guests, including his friends covering the league and some of the biggest names shaping it. Episodes weekly on Tuesdays and Thursdays.
Fiebres Lúcidas
By shows
¿Qué pasa cuando la curiosidad se vuelve una fiebre? Fiebres Lúcidas es una travesía sonora por las obsesiones científicas que transformaron a Colombia. Siete vidas, siete décadas, siete preguntas que ardieron hasta volverse descubrimientos. En un país acostumbrado a narrarse desde el conflicto, esta serie cuenta otra historia: la de la pasión, la persistencia y quienes convierten una pregunta en legado. Un pódcast de la Fundación Alejandro Ángel Escobar, conmemorando 70 años premiando la ciencia y la solidaridad. Producido por Akorde Media.
IHIP News
By shows
Deep in a red state, progressive podcasters, Jennifer Welch and Angie “Pumps” Sullivan share how they *really feel* about political news. Their comedic, feel-good takes will drop twice weekly, possibly more, if sh*t really hits the fan.
Friends Keep Secrets
By shows
Welcome to Friends Keep Secrets: a first-of-its-kind show from best friends benny blanco, Lil Dicky (Dave Burd), and Dave’s wife, Kristin Batalucco. With more than 18 hidden cameras rigged throughout Dave and Kristin’s LA home, the show brings viewers inside an intimate hang with the hosts' real-life friendships and the guests that pop in. This isn’t a formal interview show. They might cook, record a song, play a game, or simply hang out. Blending elements of a podcast, livestream, and sitcom, Friends Keep Secrets captures the magic of being in the room with the hosts and the people they cherish most.