The Science & Treatment of Bipolar Disorder
Descripción del Episodio
In this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.’ I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsorsAG1: https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Waking Up: https://wakingup.com/huberman
Momentous: https://livemomentous.com/huberman
Timestamps(00:00:00) Bipolar Disorder
(00:03:42) Tool: Appetite Suppression & GLP-1, Parallel Pathways, Yerba Mate
(00:9:19) Sponsors: AG1, LMNT
(00:14:24) Prevalence & Severity of Bipolar Disorder
(00:16:30) Bipolar Disorder I, Diagnostic Criteria of Mania
(00:28:58) Bipolar Disorder II, Individual Variability
(00:33:07) Bipolar I vs. Bipolar II: Manic, Depressive & Symptom-Free States
(00:38:20) Consequences of Bipolar Disorder, Heritability
(00:46:53) Bipolar Disorder vs. Borderline Personality Disorder
(00:51:51) Mania & Depression, Negative Impacts
(00:53:06) History of Lithium Treatment
(01:02:44) Lithium Treatment & Side-Effects
(01:05:05) Effects of Lithium: BDNF, Anti-inflammatory & Neuroprotection
(01:10:10) Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity
(01:17:11) Neural States & Mania, Parietal Lobe & Limbic System
(01:22:58) Homeostatic Plasticity, Synaptic Scaling, Lithium & Ketamine
(01:36:00) Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal & Social Rhythm Therapy
(01:43:18) Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS)
(01:48:01) Psylocibin, Cannabis
(01:51:50) Lifestyle Support, Supplements: Inositol & Omega-3 Fatty Acids
(02:03:31) Omega-3s, Membrane Fluidity & Neuroplasticity
(02:06:44) Mania, Creativity & Occupations
(02:15:33) Bipolar Disorder: Diagnosis, Neural Circuits & Treatment
(02:17:45) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter
Learn more about your ad choices. Visit megaphone.fm/adchoices
Episodios Recientes
Más podcasts de Sociedad y Cultura
Ver toda la categoría →
Dumb Blonde
By shows
<p>Asking the questions others are afraid to. Bunnie XO host of the Dumb Blonde podcast – the ultimate destination for comedy, trending and lifestyle. Get ready to dive into hilarious discussions about relationships, trauma, embarrassing moments, and all the realness life throws at us. Join Bunnie every week to laugh, relate, and embrace your inner healing.</p>
The Snare
By shows
In 1996, 18-year-old Angie Dodge is found brutally murdered in her Idaho Falls home. Police zero in on a suspect and put a man behind bars. But as the years pass, doubts emerge about whether the real killer was ever caught. Leading the fight for answers is an unlikely advocate: Angie’s own mother, who embarks on a decades-long mission to uncover the truth. A six-part series from 20/20 and ABC Audio, hosted by Maggie Rulli. New episodes Tuesdays.
Joy 101 with Hoda Kotb
By shows
<p>Joy is essential.</p> <p>And it's also elusive. You can't order it, borrow it, or simply hope it into life.</p> <p>But now, there's a new and exciting way to start your journey toward a more joyful existence: The Joy 101 Podcast with Hoda!</p> <p>Best known for her Emmy-winning work and co-anchoring <em>Today,</em> Hoda Kotb infuses her authenticity, curiosity, and warmth into conversations with the world’s most fascinating people. Entertainment legends, sport icons, wellness experts, and everyday folks will share how they find, allow, and experience joy. Hoda will offer her own tips and takes on seeking a more balanced, harmonious life. </p> <p>If you're craving inspiration, support, and useful tools to maximize your joy, tune in to these candid, uplifting, and moving on-air chats.</p> <p>Joy after a breakup, joy as an empty-nester, joy after loss, joy as a caretaker — Hoda's new podcast will speak to you.</p> <p>Joy 101 with Hoda Kotb, an iHeartPodcast.</p>
La Silla: On The Record
By shows
Cada semana contamos movidas de poder en Colombia a través de la voz de sus protagonistas. Un podcast de La Silla Podcasts.
Dinero Más Inteligente
By shows
El dinero no solo se gana, se entiende. <br /> En El Dinero Más Inteligente, Valeria Ovalle presenta la economía y Juan Carlos Herrera la conecta al mundo de inversiones. Una conversación entre razón y estrategia para entender el mundo financiero sin complicaciones. <br /> By GBM <br /> Síguenos en <b><a href="https://www.instagram.com/gbmplus_?igsh=czBzOG5mazBwMmlj&utm_source=qr">Instagram</a><b>.</b></b>
Lo que NO se habla con Fer Flores
By shows
Contenidos para construir una Humanidad con H mayúscula con perspectiva psicoanalista, médica, legal, antropológica y espiritual.
After the Whistle with Brendan Hunt and Rebecca Lowe
By shows
<p>Rebecca Lowe (Fox Sports) and Brendan Hunt (‘Ted Lasso’) are teaming up again to take on the 2026 World Cup! They’ll ride an emotional roller coaster together as 48 teams play 104 action-packed matches across the U.S., Canada, and Mexico. They’ll bring you all the joy and the drama, the hope and the heartbreak — and help you understand the matchups and personalities that will make this the biggest sporting and cultural event of our lifetimes</p><p>‘After the Whistle With Brendan Hunt and Rebecca Lowe’ is an Apple News Original podcast presented by Verizon.</p>
